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Homologous Recombination Deficiency (HRD)
- Target
- HRD
- Molecular classification
- Genomic Instability, DNA Repair Deficiency
01
Overview
Homologous recombination deficiency (HRD) refers to the impaired ability of cells to repair DNA double-strand breaks (DSBs) through the homologous recombination repair (HRR) pathway. This deficiency is often caused by mutations or functional loss in key HR genes, leading to genomic instability and increased sensitivity to certain cancer therapies like PARP inhibitors and platinum-based chemotherapies. HRD is frequently observed in cancers such as breast, ovarian, prostate and pancreatic cancers.
- Other names
- Homologous Recombination-DeficientHR DeficiencyHRR Deficiency
02
Mechanism of action
Synthetic lethality via PARP inhibition; increased sensitivity to DNA damaging agents
03
Biological functions
DNA repairGenome maintenanceCell cycle regulation
04
Disease associations
CancerCancer predispositionTumorigenesis
05
Safety considerations
Myelosuppression with PARP inhibitorsDevelopment of resistance to PARP inhibitorsSecondary malignancies with platinum-based chemotherapy
06
Interacting drugs
PARP inhibitors
1 more in the full profile.
07
Biomarkers
BRCA1 mutationsBRCA2 mutationsATM mutationsPALB2 mutationsRAD51C mutationsRAD51D mutationsTumor Mutational Burden (TMB)Genomic scar assays
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