HORMA domain-containing protein 1 (HORMAD1)

HORMA domain-containing protein 1 (HORMAD1) is a chromatin-binding protein with a HORMA domain, originally expressed in human germ cells and required for proper meiotic progression, including the regulation of DNA double-strand breaks, formation of the synaptonemal complex, and meiotic checkpoint signaling[1][3][5]. In cancers such as triple-negative breast cancer and lung adenocarcinoma, HORMAD1 is aberrantly expressed and acts as a driver of genomic instability, often causing homologous recombination repair deficiency and making such tumors sensitive to DNA-damaging agents and PARP inhibitors[2][1]. HORMAD1’s restricted expression profile makes it both a biomarker and a therapeutic target, especially in malignancies displaying cancer/testis antigen characteristics[1][2][3].

Other names

Cancer/testis antigen 46 (CT46)NOHMADKFZP434A1315Newborn ovary HORMA proteinTestis tissue sperm-binding protein Li 86PHORMAD1HORMA domain-containing protein 1Cancer/testis antigen 46CT46

Synthetic lethality: drugs that exploit homologous recombination deficiency, e.g., PARP inhibitors Increased DNA damage/cytotoxicity through replication stress Targeting of TLS polymerases to selectively inhibit HORMAD1-overexpressing tumor cells