Host–Microbial Biological System

Host–Microbial Biological Systems describes the dynamic relationships between a host (any living organism) and the microbial communities (microbiota) that live in or on it. These interactions encompass parasitic, mutualistic, and commensal relationships and play essential roles in host immunity, metabolism, neurological function, disease susceptibility, and homeostasis[1][2][3][5][6]. The system is defined by its complexity and mutual influence, involving metabolic, immune, and signaling communications. It cannot be classified as a specific receptor, enzyme, transporter, or other canonical drug target, but rather as a subject of systems biology research integral to understanding health and disease states. While these systems are not directly targeted by drugs as a single entity, manipulating the microbiota (via antibiotics, probiotics, diet, or fecal transplants) can indirectly affect host health and disease outcomes[4][5].

Other names

Host–Microbiome SystemHost–Microbe InteractionHolobiont SystemHost–Microbial Axis