Host adaptive immune receptors recognizing Infectious Bursal Disease Virus VP2 (BCR/TCR (IBDV VP2))

Host adaptive immune receptors recognizing IBDV VP2 refer to the specialized B-cell receptors (BCRs) and T-cell receptors (TCRs) in avian species, particularly chickens, that specifically bind to the VP2 protein of the Infectious Bursal Disease Virus (IBDV) [1]. VP2 is the major structural protein of the IBDV capsid and serves as the primary target for neutralizing antibodies due to its highly immunogenic hypervariable region [2]. The interaction between VP2 and these adaptive receptors is the cornerstone of the host's protective immune response, leading to the production of antibodies and the activation of cell-mediated immunity [3]. In veterinary pharmacology, these receptors are the intended targets of vaccination strategies designed to prevent Gumboro disease, a highly contagious viral infection that causes significant economic losses in the poultry industry by destroying B-lymphocytes in the Bursa of Fabricius [4]. Effective engagement of these receptors by vaccine antigens is crucial for inducing long-lasting immunity and preventing the immunosuppression associated with IBDV infection [1]. However, the high mutation rate of the VP2 gene allows the virus to evolve and escape recognition by existing adaptive immune receptors, necessitating the continuous development of updated vaccines [2, 4]. [1] Müller, H., et al. (2003). Archives of Virology. [2] Letzel, T., et al. (2007). Journal of General Virology. [3] Rautenschlein, S., et al. (2002). Veterinary Immunology and Immunopathology. [4] Dey, S., et al. (2019). Poultry Science.

Other names

Chicken B-cell receptorChicken T-cell receptorIBDV-specific BCRIBDV-specific TCRSurface Immunoglobulin M (sIgM) recognizing VP2

Antigen-specific activation of B-cell and T-cell receptors leading to signal transduction, clonal expansion, cytokine production, and the generation of neutralizing antibodies and memory cells.