Host and microbial systems

Host and microbial systems refer to the complex ecological and functional interactions between a host organism and the diverse communities of microorganisms, including bacteria, viruses, and fungi, that reside within or on it [1]. This entry is categorized as incorrect because it represents a broad biological framework or research field rather than a specific molecular target like a single receptor or enzyme [2]. These systems are essential for maintaining host health, as the microbiome contributes to the maturation of the immune system, the synthesis of vitamins, and the metabolism of dietary fibers [3]. Dysregulation within these systems, often termed dysbiosis, is a key driver in the development of inflammatory bowel disease, obesity, and various infectious diseases [4]. While not a single target, these systems are modulated by a wide array of therapeutics, ranging from traditional antibiotics that eliminate pathogens to probiotics and fecal transplants intended to restore ecological balance [5].

Other names

Host-microbe interactionsHost-pathogen interactionsMicrobiome-host interfaceCommensal-host systemsHost-microbiota crosstalk

Modulation of microbial population dynamics, inhibition of microbial cell wall synthesis, and regulation of host inflammatory signaling pathways.