Host cell factor C2 (HCFC2)

Host cell factor C2 (HCFC2, also known as HCF-2) is a broadly expressed protein member of the host cell factor family, with a structure characterized by C-terminal fibronectin type III repeats and a beta-propeller domain mediating interactions with viral proteins such as herpes simplex virus VP16[1][3]. Unlike its paralog HCFC1, which is essential for viral transactivation, HCFC2 does not initiate viral infection but functions primarily as a nuclear transcriptional regulator. It localizes to the nucleolus where it counteracts cell proliferation programs and promotes differentiation, affecting gene expression patterns related to development and cellular morphogenesis[1]. In addition, variable HCFC2 transcript expression has been associated with behavioral flexibility in mouse models, indicating potential influences on neural regulation and cognition[1]. Despite its involvement in transcriptional control, there is no direct evidence to suggest HCFC2 is a common therapeutic target or that it is implicated in major human diseases, nor are there any approved modulators or drugs that selectively interact with it[3][4][1].

Other names

HCF-2HCF2host cell factor 2C2 factorHCFC2_HUMAN

Not applicable; no drugs, inhibitors, or therapeutic modulators specifically listed