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Host Cell Ribosome-Mediated Translation of Encoded Antigens

Molecular classification: Biological Process, Translation, Protein Synthesis

Overview

The process by which host cell ribosomes translate genetic material encoding antigens (e.g., from mRNA vaccines or viral vectors) into proteins. These newly synthesized antigens are then processed and presented by the host immune system, leading to both humoral (antibody-mediated) and cellular (T-cell-mediated) immune responses.

Other names: Ribosome-mediated antigen translationAntigen translation by host ribosomesmRNA translation in vaccinationViral antigen synthesis by ribosomes

Mechanism of action

Ribosomes translate mRNA encoding antigens into proteins, which are then processed and presented to the immune system, leading to adaptive immunity.

Biological functions

Protein synthesisAntigen productionImmune response generationMHC Class I presentationMHC Class II presentation

Disease associations

InfectionVaccine-mediated immunityCancer (in some contexts, e.g., oncolytic viruses)

Safety considerations

Off-target translationUnintended immune responsesInflammationAutoimmunity (rare)

Interacting drugs

mRNA vaccines

2 more in the full profile.

Biomarkers

Antigen-specific antibody titersT-cell activation markers (e.g., IFN-γ production)MHC-peptide complex presentation

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