Host extracellular matrix and plasma proteins (ECM and plasma proteins)

Host extracellular matrix (ECM) and plasma proteins represent a diverse group of molecules that provide structural support to tissues and circulate in the blood to maintain homeostasis [Wikipedia, 2021]. This collective target includes proteins such as collagen, fibronectin, laminin, fibrinogen, and albumin [MDPI, 2022]. In the context of infectious diseases, these proteins serve as critical docking sites for pathogens like Staphylococcus aureus, which utilize specialized surface adhesins known as MSCRAMMs to colonize host tissues and evade the immune system [NIH, 2010; MDPI, 2022]. Therapeutically, this group is targeted by agents that aim to disrupt pathogen-host interactions, modulate wound healing, or regulate blood coagulation [ResearchGate, 2024]. While not a single molecular entity, the interaction between drugs and these host proteins is a fundamental aspect of pharmacology, influencing both drug distribution and therapeutic efficacy in treating infections and fibrotic diseases [Veterian Key, 2022].

Other names

Host adhesive matrix moleculesExtracellular matrix and serum proteinsHost ECM and plasma proteinsHost-derived adhesive proteins

Drugs targeting these proteins typically act by modulating tissue remodeling, inhibiting bacterial adhesion, or regulating the coagulation cascade. For example, thrombolytics activate plasminogen within the plasma to dissolve clots, while collagenases degrade specific ECM components to treat fibroproliferative conditions like Dupuytren's contracture. Additionally, anti-adhesive strategies aim to block the interaction between pathogen surface proteins (e.g., MSCRAMMs) and host ECM components to prevent colonization and infection.