Host factors involved in Poliovirus type 2 replication and translation

Host factors involved in Poliovirus type 2 replication and translation refers to the diverse set of cellular proteins and pathways that Poliovirus type 2 (PV2) hijacks to facilitate its life cycle. This group includes the cell surface receptor CD155 (PVR), which mediates viral entry, and various IRES trans-acting factors (ITAFs) such as PCBP2, PTB, and La protein that are required for the cap-independent translation of the viral RNA. Additionally, host enzymes like Phosphatidylinositol 4-kinase beta (PI4KB) and the guanine nucleotide exchange factor GBF1 are recruited to remodel intracellular membranes into specialized replication organelles. These factors are essential for the pathogenesis of poliomyelitis, supporting viral replication in the gastrointestinal tract and potential invasion of the central nervous system. Therapeutic strategies targeting these host factors aim to provide a higher barrier to viral resistance compared to direct-acting antivirals. Experimental drugs such as PI4KB inhibitors (e.g., PIK-93) and GBF1 inhibitors (e.g., Brefeldin A) have demonstrated the ability to suppress PV2 replication by interfering with these essential host-virus interactions.

Other names

Poliovirus type 2 host factorsPV2 host factorsHost factors for PV2 replicationHost factors for PV2 translation

Inhibition of host proteins required for viral entry, IRES-mediated translation, and replication organelle formation, such as PI4KB and GBF1.