Host Fc receptors and Complement system (No universally recognized abbreviation for the combined entity.)

Fc receptors are immune cell surface proteins that bind the Fc portion of antibodies, linking adaptive and innate immunity by triggering cell-mediated responses such as phagocytosis, cytotoxicity, and immunomodulation[2][5][6]. Complement receptors recognize fragments generated by complement activation (e.g., C3b, C5a), mediating phagocytosis, chemotaxis, and regulation of inflammation[1][3][4]. Both systems are central to host defense but are also implicated in autoimmune and inflammatory diseases. They interact and integrate signaling networks, with some therapeutic drugs targeting their functions to treat immune-mediated disorders[1][2][3][4][6][7]. This entry refers to a functional group, not a precise molecular target, and requires refinement for accurate drug discovery or clinical application.

Other names

Fc receptors (including FcγR, FcαR, FcεR, etc.)Complement system receptors (e.g., CR1, CR2, CR3, CR4, C3aR, C5aR)Antibody Fc binding proteinsImmunoglobulin Fc receptorsComplement cascade receptors

Fc receptor targeting: - Modulation of phagocytosis and ADCC by engaging or blocking FcγRs - Inhibition of FcγR signaling to dampen immune responses - Complement system targeting: - Inhibiting complement activation to prevent tissue damage/inflammation - Blocking complement receptor-mediated cell activation or chemotaxis