Host immune and metabolic enzymes

The term Host immune and metabolic enzymes refers to a broad category of proteins rather than a single, specific therapeutic target. It encompasses a diverse array of enzymes that reside at the intersection of metabolism and immunology, a field often referred to as immunometabolism. These enzymes, such as Indoleamine 2,3-dioxygenase (IDO), Arginase 1, and various kinases in the PI3K/AKT/mTOR pathway, play critical roles in regulating the activation, differentiation, and effector functions of immune cells by altering the availability of nutrients or producing bioactive metabolites. In many disease states, particularly cancer and chronic infections, these enzymes are dysregulated to create an immunosuppressive environment that allows for disease progression. While many individual enzymes within this group are valid therapeutic targets, the collective phrase is too broad for specific drug-target characterization and typically serves as a functional classification in research and drug discovery contexts.

Other names

Immunometabolic enzymesHost metabolic enzymesImmune-modulating metabolic enzymes

Inhibition or activation of specific metabolic pathways to modulate immune cell function and phenotype.