Host Immune and Metabolic Systems

The host immune and metabolic systems together form a complex network coordinating organismal responses to internal and external stimuli. The immune system defends against pathogens by activating innate and adaptive responses, while the metabolic system regulates energy production and homeostasis. Their interaction, termed immunometabolism, ensures that immune cell activation and function are tightly linked to cellular metabolic states, influencing the outcome of infection, inflammation, and other diseases. Systems biology approaches use omics analyses and integrated models to study the interplay between immune signaling and metabolic reprogramming, revealing key pathways and potential drug targets for diseases at the intersection of immunity and metabolism. There is no singular molecule, receptor, or druggable target corresponding to "Host Immune and Metabolic Systems." For therapeutic development, focus should shift to specific molecules or pathways (e.g., Toll-like receptors, interferons, metabolic enzymes) within this broader network.

Other names

Immunometabolic systemImmunometabolismImmune-metabolic axis

Modulation of immune cell metabolism; Regulation of cytokine signaling; Alteration of cell signaling pathways to affect immune and metabolic outcomes.