Host immune recognition of Burkholderia pseudomallei antigens

“Host immune system recognition of Burkholderia pseudomallei antigens” is not a single defined molecular target, but rather describes the broad immunological processes by which the human immune system detects and responds to antigens from the Gram-negative bacterium Burkholderia pseudomallei, the agent of melioidosis. Recognition primarily occurs via host pattern recognition receptors (such as TLR4), which detect pathogen-associated molecular patterns like lipopolysaccharide (LPS). Other major immunogenic structures include the polysaccharide capsule, flagellin, outer membrane proteins, and secreted effector proteins[1][7][5][4]. The immune response involves both antibody production and cell-mediated immunity (notably CD4+ T cells specific to dominant epitopes), with both innate and adaptive arms playing essential roles in controlling infection and influencing disease outcome[1][5]. The pathogen, in turn, has evolved a wide array of immune evasion mechanisms, such as altering LPS and capsular composition, modulating cytokine responses, inhibiting complement deposition, and downregulating host immune signaling[4][6][8]. Due to these complexities, this phrase is not a canonical drug or therapeutic target but rather refers to the ensemble of host-pathogen interactions critical to pathogenesis and immunity in melioidosis.

Other names

Host immunity to Burkholderia pseudomalleiImmune response to Burkholderia pseudomalleiHost-pathogen interaction in melioidosis