Host Immune Response Modulation via Regulatory T Cell Induction (Treg Induction)

Regulatory T cells (Tregs) are a specialized subpopulation of T cells that play a central role in modulating the host immune response, maintaining immune homeostasis, preventing autoimmunity, and limiting excessive inflammation. The induction or expansion of regulatory T cells is a key strategy for modulating the immune system in various disease contexts. Approaches to modulate this pathway include cytokine therapy (e.g., low-dose IL–2), antibody-based depletion/blockade, and small molecule modulators targeting signaling pathways involved in induction/function.

Other names

Regulatory T Cell TherapyTreg ModulationImmune Tolerance InductionFoxp3 InductionTreg Expansion

Enhancement or inhibition of regulatory T cell activity through cytokine modulation, cell-cell interaction blockade, or metabolic disruption.