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Host immune system modulation" is not a specific molecule or receptor but rather a broad biological process referring to the regulatory adjustment of the host's immune response. This can involve either stimulation or suppression of various components of the immune system to achieve homeostasis or therapeutic goals[1][3][4]. Immunomodulation can be natural (such as self-regulation via regulatory T cells and cytokines) or induced by drugs and therapies (immunotherapy), aiming to enhance defense against infections, reduce harmful inflammation, or treat diseases like cancer[1][2][4]. Because it does not refer to a single molecular entity but instead describes an overall strategy or effect on the immune network, it is not considered a canonical therapeutic target such as a receptor, enzyme, transporter, etc.[1][3].
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