Host-microbiome interface

The **host-microbiome interface** is the anatomical and functional boundary where a host organism (such as human epithelial or mucosal surfaces) interacts with its resident microbial community (microbiota)[1][3][6]. This interface includes physical structures (e.g., gut mucosa), secreted compounds, and cellular and molecular signals coordinating immune tolerance, defense, metabolism, and homeostasis. The interface is dynamic, with mutual influences between host and microbes shaping health outcomes and responses to disease. Disruption of homeostasis at this interface (dysbiosis) is implicated in a wide range of diseases, including inflammatory, metabolic, and infectious conditions. Therapeutic manipulation of the host-microbiome interface (using probiotics, prebiotics, or fecal transplants) aims to restore or optimize these interactions[2][6][7].

Other names

Host–microbe interfacehost–microbiome boundaryhost–microbiota interface

Modulation of microbial composition Restoration or alteration of barrier function Immune modulation Alteration of local or systemic metabolites