Host or viral molecular targets

The term 'Host or viral molecular targets' refers to a broad category of biological entities rather than a specific, individual therapeutic target. In the context of pharmacology and virology, this classification encompasses both viral proteins, such as polymerases, proteases, and surface glycoproteins, and host cell factors, such as receptors, entry co-factors, and signaling molecules, that are essential for the viral life cycle [NIH, 2023]. Because this entry represents a high-level grouping of diverse molecules with distinct structures and functions, it cannot be characterized by a single set of molecular classifications, mechanisms of action, or safety profiles. Specific examples within this category include the SARS-CoV-2 Spike protein (viral) or the Human Angiotensin-Converting Enzyme 2 (host) [PubMed, 2021]. For drug development purposes, researchers must identify specific proteins within this category to design targeted therapies, which are often classified as either direct-acting antivirals or host-directed therapies [Nature Reviews Drug Discovery, 2020]. Consequently, this term is considered too broad to serve as a single therapeutic target in a structured database.

Other names

Viral targetsHost factorsHost-pathogen interface targetsAntiviral targets

Not applicable as this is a broad category encompassing multiple distinct mechanisms.