Host regenerative and stromal cells via PDLSC-secreted growth factors and their receptors

The term Host regenerative and stromal cells via PDLSC-secreted growth factors and their receptors refers to a complex paracrine signaling axis rather than a single molecular target. Periodontal Ligament Stem Cells (PDLSCs) are multipotent mesenchymal stem cells that play a pivotal role in the maintenance and regeneration of periodontal tissues by secreting a diverse array of growth factors, such as Vascular Endothelial Growth Factor (VEGF), Hepatocyte Growth Factor (HGF), and Transforming Growth Factor-beta (TGF-beta) [PMID: 31464478]. These secreted factors interact with their cognate receptors on neighboring host cells, including endothelial cells, osteoblasts, and immune cells, to stimulate biological processes essential for tissue engineering, such as angiogenesis, cell migration, and osteogenic differentiation [PMID: 33061988]. This mechanism is a primary focus in regenerative medicine for treating periodontitis and alveolar bone defects, where the PDLSC secretome is being explored as a cell-free therapeutic alternative to direct stem cell transplantation [PMID: 28210531]. Because this entry encompasses a broad network of ligands and receptors across multiple cell types, it is classified as a biological pathway or therapeutic mechanism rather than a discrete drug target [PMID: 30101505].

Other names

PDLSC secretomePeriodontal ligament stem cell paracrine signalingPDLSC-mediated tissue regenerationPDLSC-derived growth factor signaling

Periodontal Ligament Stem Cells (PDLSCs) secrete a variety of bioactive molecules, including growth factors and cytokines, which bind to specific receptors on host regenerative and stromal cells to activate signaling pathways that promote tissue repair, angiogenesis, and immunomodulation.