Host systemic physiology

Host systemic physiology encompasses the complex, interconnected biological processes and homeostatic mechanisms that maintain the functional integrity of an entire organism [1]. Unlike discrete molecular targets such as receptors or enzymes, systemic physiology represents the aggregate output of all cellular and organ-level activities [2]. It is the primary context in which drug-target interactions occur, and its modulation is the ultimate goal of most systemic therapies, such as those for hypertension or diabetes [3]. Dysregulation of host systemic physiology is a hallmark of critical illnesses, including sepsis and multi-organ failure, where the failure of one system cascades into others. For drug development, monitoring systemic parameters is essential for identifying off-target effects and ensuring that molecular-level interventions do not result in deleterious organism-wide consequences [3]. Consequently, while not a target itself, host systemic physiology is the fundamental benchmark for evaluating therapeutic efficacy and safety. Sources: [1] StatPearls, Physiology, Homeostasis; [2] Britannica, Human Physiology; [3] Nature Reviews Drug Discovery, A comprehensive map of molecular targets of approved drugs.

Other names

Whole-body physiologySystemic homeostasisOrganismal physiologyHost physiology

Not applicable; host systemic physiology is a physiological state and not a discrete molecular target.