Host tissues and immune cells via paracrine factors and adhesion molecules

The phrase "Host tissues and immune cells via paracrine factors and adhesion molecules" describes a complex physiological interaction mechanism rather than a single molecular target. This terminology is primarily used in the field of regenerative medicine to explain the therapeutic effects of mesenchymal stem cells (MSCs) and other cell-based therapies (PMID: 29958483). The mechanism involves the secretion of a diverse array of paracrine factors, such as cytokines, chemokines, and growth factors, which modulate the activity of host immune cells and promote tissue regeneration (PMID: 30107430). Additionally, the expression of adhesion molecules on the surface of therapeutic cells allows for direct physical interaction with host cells and facilitates homing to sites of injury (PMID: 24591452). These interactions are critical for the immunomodulatory properties of MSCs in treating conditions like graft-versus-host disease and autoimmune disorders. Because this term encompasses a broad range of proteins and signaling pathways, it is considered a descriptive mode of action rather than a discrete, druggable target. Consequently, it does not fit the standard definition of a therapeutic target like a specific receptor or enzyme.

Other names

Paracrine and adhesion-mediated signaling mechanismMSC-host interaction pathway

Modulation of host immune cells and tissues through the secretion of soluble paracrine factors and direct physical contact mediated by cell-surface adhesion molecules.