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Target intelligence / Profile preview
House Dust Mite Allergen-Specific Immune Cells (HDM-specific Immune Cells)
- Target
- HDM-specific Immune Cells
- Molecular classification
- T lymphocytes, B lymphocytes, Innate Lymphoid Cells, Dendritic Cells, Immune cells, Adaptive immune cells, Innate immune cells
01
Overview
House dust mite (HDM) allergen-specific immune cells are a diverse population of immune cells, including T cells, B cells, ILC2s, and dendritic cells, that recognize and respond to HDM allergens. These cells mediate allergic inflammation in diseases like asthma, rhinitis, and atopic dermatitis. Activation involves both adaptive (T cell-dependent IgE production) and innate (epithelial cell activation, ILC2 stimulation) pathways. Targeting these cells or their products is a key strategy for treating HDM-related allergic diseases.
- Other names
- HDM-specific T cellsHDM-specific B cellsHDM-specific ILC2sHDM-specific Dendritic cellsDer p 1-specific T cellsDer f 1-specific B cellsHouse dust mite reactive immune cells
02
Mechanism of action
Varies depending on the drug; includes reducing IgE levels, suppressing Th2 responses, inhibiting cytokine signaling, and reducing inflammation.
03
Biological functions
Antigen recognitionCytokine productionAntibody productionInflammationImmune responseAllergic sensitizationAntigen presentation
04
Disease associations
AsthmaAllergic rhinitisAtopic dermatitisAllergic diseaseHypersensitivity
05
Safety considerations
Anaphylaxis (allergen immunotherapy)Immunosuppression (corticosteroids)Increased risk of infections (some biologics)Injection site reactionsBlack box warnings for some biologics (rare)
06
Interacting drugs
Allergen immunotherapy
6 more in the full profile.
07
Biomarkers
HDM-specific IgE levelsHDM-specific IgG4 levelsPeripheral blood eosinophil countFractional exhaled nitric oxide (FeNO)Serum periostin levelsT cell cytokine profiles (IL-4, IL-5, IL-13)Basophil activation test
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