House dust mite allergen-specific immune response modulation (HDM-specific immune modulation)

House dust mite (HDM) allergen-specific immune response modulation refers to the complex interplay between HDM allergens and the human immune system, leading to allergic sensitization and inflammation. This process involves both innate and adaptive immunity, with a strong bias toward Th2-type responses that drive conditions such as allergic rhinitis, atopic dermatitis, and asthma. Key molecules include HDM allergens such as Der p 1 and Der p 2, pattern recognition receptors like TLRs, and cytokines such as IL-4, IL-5, and IL-13. Understanding these mechanisms underpins strategies for immunotherapy and other treatments targeting specific molecules/receptors involved in this cascade.

Other names

HDM allergyDust mite sensitizationDer p 1-induced immune responseDer p 2-induced immune response

Various, depending on the drug: antihistamines block histamine receptors; corticosteroids suppress inflammation; omalizumab neutralizes IgE; immunotherapy aims to induce tolerance.