Hox gene family (Hox (or HOX, where individual genes may be abbreviated as HOXA1, HOXB9, etc.))

Hox genes are a subset of homeobox genes encoding transcription factors that bind DNA and regulate gene expression during development, ensuring the correct structures and organs form in the appropriate positions along the anterior-posterior axis[1][3][7]. The order and arrangement of Hox genes in their clusters is mirrored by their pattern of expression in the embryo (spatial and temporal colinearity), which is crucial for body plan specification in animals[5][7][1]. Dysregulation or mutation of Hox genes is linked to cancer, developmental disorders, and congenital malformations. These genes are not receptors, enzymes, or traditional pharmacological drug targets but serve as master regulators of gene networks that govern cell fate and body patterning[7][3][1].

Other names

Homeobox genesHOX genesANTP class homeobox geneshomeotic genes

N/A (No drugs have a mechanism of action specific to Hox gene family)