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HOXD antisense growth-associated long non-coding RNA (HAGLR)
- Target
- HAGLR
- Molecular classification
- Long non-coding RNA (lncRNA), Non-protein coding RNA, Located in the HOXD gene cluster
01
Overview
HAGLR (HOXD antisense growth-associated long non-coding RNA) is a long non-coding RNA gene found in the HOXD gene cluster on chromosome 2. It is transcribed antisense to HOXD1 and HOXD3, and its primary transcript shows several splice variants. The molecule has been implicated in developmental processes, especially in growth trajectories and gut development in model organisms. Historically, deletion of HAGLR in mice causes reduced postnatal growth ("midget" phenotype), but subsequent studies suggest that effects attributed to HAGLR may instead be due to disruption of neighboring genes such as HOXD3. In humans, HAGLR has been associated with certain cancers, acting as a possible biomarker, though its mechanistic function, clinical utility, and biological significance remain incompletely understood[1][2][3].
- Other names
- HOXD-AS1MdgtMIR7704HGSTEELMIR7704 host geneSpliced-transcript endothelial-enriched lncRNAHOXD cluster antisense RNA 1 (non-protein coding)MIR7704 host
02
Biological functions
Regulation of gene expression in the HOXD clusterAntisense transcription potentially involved in transcriptional interferenceSuggested involvement in developmental growth trajectories (e.g., postnatal growth), though studies have failed to corroborate a definitive mechanistic function independent from flanking protein-coding genes
03
Disease associations
Cancer (reported association with Castration-Resistant Prostate Carcinoma and Ovary Epithelial Cancer; may act as a biomarker or be dysregulated in cancer)Growth retardation (in murine genetic models, but human relevance is unclear)
04
Biomarkers
Potential as a biomarker in certain cancer types (e.g., prostate and ovarian cancers)Experimental association as a marker for growth phenotype in mice
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