HSD11B1 antisense RNA 1 (HSD11B1-AS1)

HSD11B1 antisense RNA 1 is a human long non-coding RNA transcribed from the antisense strand of the HSD11B1 locus, with expression profiles suggesting roles in immune response regulation, suppression of tumor proliferation and metastasis, and modulation of inflammatory pathways such as TLR signaling. Downregulation of HSD11B1-AS1 has been associated with poor prognosis, advanced disease stages, and increased tumor cell invasiveness in melanoma, making it a promising candidate for diagnostic, prognostic, and therapeutic development in cancer and inflammatory diseases. Its biological effects are reportedly mediated through modulation of immune cell infiltration and activity (particularly T cells, B cells, and dendritic cells), as well as interaction with immune-related signaling pathways. HSD11B1-AS1 is validated as a cancer-associated and immune-regulatory lncRNA, with clinical and molecular evidence supporting its biomarker potential and therapeutic interest, particularly in melanoma and Kawasaki disease. No approved drugs or clinical therapies currently target HSD11B1-AS1 directly, and its safety profile remains unexplored.

Other names

HSD11B1 antisense RNA 1LOC101930244RP1 28O101lnc-LAMB3-1 (in some breast cancer literature)

Modulation of immune cell infiltration (enhances recruitment of T cells, B cells, dendritic cells); Regulation of cytokine signaling and immune cell activation