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Target intelligence / Profile preview
HSD17B3 antisense RNA 1 (HSD17B3-AS1)
- Target
- HSD17B3-AS1
- Molecular classification
- Long non-coding RNA (lncRNA), Antisense RNA, Other
01
Overview
HSD17B3 antisense RNA 1 (HSD17B3-AS1) is a long non-coding RNA (lncRNA) gene located on chromosome 9 (ENSG00000232283) and classified as an antisense transcript[1][3][6]. It does not code for a protein but potentially modulates the expression of neighboring genes through non-coding RNA regulatory mechanisms. Recent research has implicated HSD17B3-AS1 as a novel regulator involved in inflammation during acute phases of COVID-19, with evidence suggesting that downregulation of HSD17B3-AS1 by nanocurcumin can ameliorate proinflammatory cytokine responses and reduce complications in COVID-19 animal models[2]. There is currently limited knowledge regarding its roles in other diseases or its specificity as a therapeutic target.
- Other names
- ENST00000448857ENSG00000232283105376162
02
Mechanism of action
Downregulation by nanocurcumin leading to reduced inflammation
03
Biological functions
Regulation of inflammationRegulation of gene expressionPotential modulation of immune responseOther
04
Disease associations
COVID-19Pseudohermaphroditism (as an associated gene)Other
05
Safety considerations
Limited information; unknown safety or therapeutic challenges specific to HSD17B3-AS1 targeting
06
Interacting drugs
Nanocurcumin
07
Biomarkers
Expression levels of HSD17B3-AS1 in inflammatory response or COVID-19 severity
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