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Target intelligence / Profile preview
Hsp90 co-chaperone Cdc37-like 1 (CDC37L1)
- Target
- CDC37L1
- Molecular classification
- Other, Co-chaperone, Protein folding-related
01
Overview
Hsp90 co-chaperone Cdc37-like 1 (CDC37L1) is a cytoplasmic phosphoprotein that functions as a co-chaperone, binding to various client proteins and promoting their association with molecular chaperones Hsp70 and Hsp90 to assist in protein folding and stability. CDC37L1 is a paralog of CDC37, with reported involvement in regulating tau protein stability and processing, particularly relevant to tauopathies such as Alzheimer’s disease. While it is a protein coding gene expressed in human tissues, the direct role of CDC37L1 in disease or as a drug target is not established. There are currently no drugs or specific therapeutics targeting CDC37L1, nor documented use as a clinical biomarker.
- Other names
- Cdc37-like 1CDC37L1CDC37BHARCFLJ20639Hsp90-associating relative of Cdc37cell division cycle 37 homolog-like 1
02
Biological functions
Protein foldingProtein complex stabilizationStress responseTau regulation
03
Disease associations
Neurodegenerative disease (implicated in tauopathies including Alzheimer’s disease; limited disease associations outside this area)
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