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Target intelligence / Profile preview
HSP90AB1 associated lncRNA 1 (HSALR1)
- Target
- HSALR1
- Molecular classification
- Other, Long non-coding RNA, lncRNA
01
Overview
HSP90AB1 associated lncRNA 1 (HSALR1) is a long non-coding RNA transcribed from the human genome, identified based on its association with HSP90AB1, a molecular chaperone protein. HSALR1 has been shown to potentiate the non-classical TGF-β signaling pathway via Smad3, promoting activation of the Stat3/EZH2/FOXO3A axis, and increasing cell proliferation and resistance to apoptosis in cellular models. This lncRNA may contribute to the pathogenesis of chronic obstructive pulmonary disease (COPD)[2], and is under investigation as a promising molecular target for therapeutic intervention in this context. There is currently limited evidence about its role in other disease areas or its interaction with small-molecule drugs[4][6].
- Other names
- HSALR1HSP90AB1 associated lncRNA 1
02
Mechanism of action
For HSALR1, mechanisms involve modulation of HSP90AB1 activity, enhancement of Smad3-mediated non-classic TGF-β pathway (Stat3/EZH2/FOXO3A axis)
03
Biological functions
Regulation of gene expressionEpigenetic modulationEnhances non-classic TGF-β signaling pathway
04
Disease associations
Chronic obstructive pulmonary disease (COPD)Potential involvement in other disease contexts where HSP90AB1 function is regulated
05
Safety considerations
None directly reported for HSALR1lncRNA-based therapies in general face delivery and specificity challenges
06
Biomarkers
HSALR1 expression is proposed as a potential biomarker in COPD
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