HSPE1-MOB4 readthrough

The HSPE1-MOB4 readthrough encodes a fusion transcript resulting from naturally occurring read-through transcription between the adjacent HSPE1 (heat shock 10 kDa protein 1, also known as chaperonin 10) and MOB4 (MOB family member 4, phocein) loci on chromosome 2. This fusion transcript produces a protein that shares sequence identity with both HSPE1 and MOB4 gene products. HSPE1 is a mitochondrial co-chaperonin critical for protein folding and mitochondrial import, while MOB4 may participate in membrane trafficking and budding. The readthrough fusion is not established as a functional single protein or therapeutic target; its roles and disease associations appear to trace to the functions of the individual parental genes. Key context: - This entry is not a recognized therapeutic target but a genomic/transcriptomic artifact found in some human tissues. - Information about the biological and pharmacological properties is generally inferred from the parental genes. - Its listing as a target is often due to automated annotation pipelines capturing natural fusion transcripts, but it is not a canonical drug target in pharmacology databases. Summary: HSPE1-MOB4 readthrough is a fusion gene derived from HSPE1 and MOB4, not a conventional receptor, enzyme, or drug target, and information about it should instead focus on the individual chaperonin and membrane trafficking protein functions of its component genes.

Other names

HSPE1-PHOCNHSPE1-MOB4 proteinHSPE1-MOB4