HTR5A antisense RNA 1 (HTR5A-AS1)

HTR5A antisense RNA 1 (HTR5A-AS1), also known as HTR5AOS or HTR5A opposite strand, is a long non-coding RNA (lncRNA) gene associated with the human genome and is transcribed from the opposite strand of the HTR5A gene. HTR5A antisense RNA 1 is a long non-coding RNA transcribed from the region antisense to the HTR5A gene on chromosome 7 (Chr7:155067034-155072450, hg38). While it does not encode a protein, it is classified as an antisense RNA and part of the broader family of lncRNAs. Antisense RNAs including HTR5A-AS1 typically regulate the expression of their corresponding sense gene through diverse mechanisms, such as chromatin remodeling, transcriptional interference, or post-transcriptional regulation. Although the precise functional characterization of HTR5A-AS1 is limited in current literature, its association with lncRNA functions suggests a role in regulating nearby gene(s), possibly including HTR5A, which encodes a serotonin receptor implicated in neuropsychiatric processes. Diseases associated with HTR5A-AS1 include Autism Spectrum Disorder. General evidence from studies on antisense lncRNAs indicates a broader potential for involvement in cancer and other regulatory disease processes, but such associations remain to be specifically defined for HTR5A-AS1. There are currently no known drugs that target HTR5A-AS1, and it is not considered a direct therapeutic target like a receptor, enzyme, or transporter. There is also no available information indicating it is currently used as a biomarker or has noted safety concerns.

Other names

HTR5AOSHTR5A opposite strandHTR5A Antisense RNA 1