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Target intelligence / Profile preview
HTRA1 and ARMS2 antisense RNA 1 (HTRA1-AS1)
- Target
- HTRA1-AS1
- Molecular classification
- Other (long noncoding RNA, antisense RNA)
01
Overview
HTRA1-AS1 (HTRA1 and ARMS2 antisense RNA 1) is a long noncoding RNA that overlaps the chromosome 10q26 locus associated with age-related macular degeneration (AMD)[2][4][6]. This locus contains the protein-coding genes HTRA1 (a serine protease involved in extracellular matrix remodeling and vascular regulation) and ARMS2 (possibly involved in mitochondrial function in retinal cells). Most genetic, functional, and therapeutic research focuses on HTRA1 and ARMS2 themselves, particularly their risk alleles and protein functions, not on their antisense RNA. HTRA1-AS1 is not recognized as a receptor, enzyme, therapeutic target, or biomarker in current clinical or research literature. Structured data extraction should focus on the canonical protein-coding genes at this locus rather than the antisense transcript[2][4][6].
- Other names
- HTRA1 antisense RNA 1HTRA1-AS1ARMS2 antisense RNA
02
Biological functions
Other (potential gene regulation at the HTRA1/ARMS2 locus—no direct experimental evidence for specific biological functions of HTRA1-AS1 found in the literature.)
03
Disease associations
Other (Association with risk haplotypes for age-related macular degeneration (AMD) and potentially other retinal diseases as a locus marker, not as a functional disease gene)
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