Human adenovirus 56 (HAdV-D56)

Human adenovirus 56 (HAdV-D56) is a non-enveloped, double-stranded DNA virus belonging to the Adenoviridae family and species D [1, 17]. It was first identified in 2009 as a recombinant virus containing genetic material from HAdV-D9, 15, 26, and 29 [1, 3]. HAdV-D56 is primarily recognized as a causative agent of epidemic keratoconjunctivitis (EKC), a severe and contagious ocular infection, and has also been linked to fatal respiratory disease and emerging cases of gastroenteritis [2, 8, 10]. Unlike many other adenoviruses that use the Coxsackievirus and Adenovirus Receptor (CAR), HAdV-D56 utilizes the host cell surface protein CD46 as a primary receptor, specifically through an interaction with its hexon capsid protein [4]. In clinical practice, it is targeted by broad-spectrum antivirals such as cidofovir and brincidofovir, which function by inhibiting the viral DNA polymerase to prevent replication [12, 19]. The virus's unique recombination history and tissue tropism make it a subject of intense study for both antiviral development and the design of adenovirus-based vaccine vectors [5, 13].

Other names

HAdV-56Human adenovirus D56HAdV-D56Adenovirus 56

Inhibition of viral DNA polymerase [12, 19]