Target intelligence / Profile preview

Human Adenovirus Serotype 4 (HAdV-4)

Target
HAdV-4
Molecular classification
Virus, DNA Virus, Adenoviridae, Mastadenovirus
01

Overview

Human adenovirus serotype 4 (HAdV-4) is a nonenveloped, double-stranded DNA virus belonging to the genus *Mastadenovirus* within the family *Adenoviridae*. It is a significant human pathogen, primarily associated with outbreaks of acute respiratory disease (ARD), especially in crowded settings. It infects epithelial cells lining the respiratory tract, entering via endocytosis and replicating within the nucleus. Transmission occurs via respiratory droplets and fomites.

02

Biological functions

Viral replicationInfectionModulation of host immune responseCell entryGene expression
03

Disease associations

Acute Respiratory Disease (ARD)ConjunctivitisInfection
04

Safety considerations

Potential for outbreaks in crowded environmentsGenetic variability affecting virulence

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