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Target intelligence / Profile preview
Human Adenovirus Serotype 7 (HAdV-7)
- Target
- HAdV-7
- Molecular classification
- Virus, Adenoviridae, Human mastadenovirus B
01
Overview
Human adenovirus serotype 7 (HAdV-7) is a highly pathogenic adenovirus associated with severe respiratory illnesses, particularly in children and immunocompromised individuals. It is a non-enveloped virus with an icosahedral capsid structure and a double-stranded linear DNA genome. HAdV-7 infections are notable for causing severe pneumonia, ARDS, and toxic encephalopathy. No approved vaccine or antiviral therapy currently exists for civilians, although research into monoclonal antibody therapies is ongoing.
- Other names
- Ad7HAdV7Adenovirus 7
02
Mechanism of action
Neutralization of viral infectivity by binding to the hexon protein.
03
Biological functions
Viral replicationInfectionImmune evasion
04
Disease associations
Acute Respiratory Disease (ARD)Viral PneumoniaEncephalopathyRespiratory Failure
05
Safety considerations
High pathogenicity in children and immunocompromised individualsLack of widely available vaccinePotential for severe complications like ARDS and toxic encephalopathy
06
Interacting drugs
HMAb 3-3E (Human Monoclonal Antibody)
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