Target intelligence / Profile preview

Human adenovirus type 5 (Ad5)

Target: Ad5
Molecular classification: Virus, Adenoviridae, Mastadenovirus, Human mastadenovirus C

Overview

Adenovirus type 5 (Ad5) is a human adenovirus belonging to the family Adenoviridae. It is a medium-sized, non-enveloped virus with an icosahedral capsid structure and a linear, double-stranded DNA genome. Ad5 causes respiratory illnesses ranging from mild pharyngitis or conjunctivitis to severe pneumonia or bronchiolitis. Recombinant vectors based on Ad5 are widely used in gene therapy research but face challenges from pre-existing immunity within human populations.

Other names: Adenovirus type 5

Mechanism of action

Cidofovir shows some efficacy against ocular infections caused by adenoviruses.

Biological functions

InfectionViral replicationImmune response elicitation

Disease associations

Respiratory illnessConjunctivitisPneumoniaBronchiolitis

Safety considerations

Pre-existing immunity limits effectiveness as therapeutic vectors or vaccines.

Interacting drugs

Cidofovir

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