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Target intelligence / Profile preview
Human aspartyl (asparaginyl) β-hydroxylase (AspH)
- Target
- AspH
- Molecular classification
- Enzyme, Dioxygenase, Type II transmembrane protein
01
Overview
Human aspartyl (asparaginyl) β-hydroxylase, encoded by the ASPH gene, is an alpha-ketoglutarate-dependent dioxygenase involved in the hydroxylation of aspartyl and asparaginyl residues within EGF-like domains of proteins. It plays a role in cell motility, adhesion, and Notch signaling. Overexpression is associated with various cancers and poor prognosis. Mutations in the ASPH gene cause Traboulsi syndrome. Alternative splicing produces multiple protein variants with diverse functions.
- Other names
- Aspartyl/asparaginyl beta-hydroxylase
02
Mechanism of action
Small-molecule inhibitors targeting hydroxylase activity can block tumor cell migration and metastasis
03
Biological functions
Protein hydroxylationCell motilityCell adhesionNotch signalingCalcium homeostasis
04
Disease associations
CancerTraboulsi syndrome
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