Human B-cell receptors and T-cell receptors recognizing Diphtheria, Tetanus, and acellular Pertussis vaccine antigens (BCR/TCR-DTacP)

The Human B-cell receptors and T-cell receptors recognizing DTacP vaccine antigens represent the diverse repertoire of immune receptors that mediate the adaptive response to Diphtheria, Tetanus, and acellular Pertussis (DTaP) vaccination. These receptors, belonging to the immunoglobulin superfamily, are expressed on the surface of B and T lymphocytes and are responsible for the specific recognition of vaccine antigens such as Diphtheria toxoid, Tetanus toxoid, and various Bordetella pertussis proteins (CDC, 2020; https://www.cdc.gov/vaccines/vpd/dtap-tdap-td/hcp/about-vaccine.html). B-cell receptors (BCRs) bind directly to these antigens to initiate the production of neutralizing antibodies, while T-cell receptors (TCRs) recognize processed antigen peptides presented by MHC molecules to coordinate cellular immunity (Janeway et al., 2001; https://www.ncbi.nlm.nih.gov/books/NBK27158/). This recognition process is the fundamental mechanism of active immunization, leading to the expansion of antigen-specific clones and the establishment of long-term immunological memory (Edwards & Decker, 2018; https://doi.org/10.1016/B978-0-323-35761-6.00032-1). While these receptors are not traditional targets for pharmacological inhibition, they are the primary focus for evaluating vaccine efficacy and are monitored through biomarkers such as antigen-specific IgG titers and T-cell frequency (Dauby et al., 2016; https://pubmed.ncbi.nlm.nih.gov/27129425/). Monitoring the diversity and affinity of these receptors provides insights into the breadth of the immune response and the duration of protection against Diphtheria, Tetanus, and Pertussis.

Other names

DTaP-specific immune receptorsAnti-DTaP BCRs and TCRsDiphtheria-Tetanus-Pertussis antigen-specific receptorsDTacP-specific lymphocyte receptors

Vaccine antigens bind to specific BCRs and TCRs, triggering signal transduction that leads to lymphocyte activation, clonal expansion, and the generation of protective memory cells and antibodies.