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Target intelligence / Profile preview
Human Carboxylesterase-1 (CES1)
- Target
- CES1
- Molecular classification
- Enzyme, Serine hydrolase, Carboxylesterase
01
Overview
Human Carboxylesterase 1 (CES1) is a serine esterase involved in the hydrolysis of various xenobiotics, drugs, and endogenous substrates. It plays a role in drug metabolism, cholesterol homeostasis, and detoxification. Genetic variants can affect drug pharmacokinetics and pharmacodynamics.
- Other names
- ACATCE-1CEHCES1A1hCE-1HMSE, HMSE1PCE-1, REH, SES1, TGHBrain carboxylesterase hBr1Cocaine carboxylesteraseEgasynLiver carboxylesterase 1Methylumbelliferyl-acetate deacetylase 1
02
Mechanism of action
Hydrolysis or transesterification of ester or amide bonds
03
Biological functions
Drug metabolismXenobiotic metabolismCholesterol ester hydrolysisFatty acid ester hydrolysisDetoxification
04
Disease associations
Non-Hodgkin lymphomaB-cell lymphocytic leukemiaChemical poisoning
05
Safety considerations
Genetic polymorphisms affect drug responseInhibition by organophosphates reduces monocyte tumor-killing activity
06
Interacting drugs
ACE inhibitors
8 more in the full profile.
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