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Target intelligence / Profile preview
Human Cell Surface Antigen CD47 (CD47)
- Target
- CD47
- Molecular classification
- Transmembrane protein, Immunoglobulin superfamily
01
Overview
Human cell surface antigen CD47 is an immunoglobulin superfamily member acting primarily through interaction with SIRPα to inhibit phagocytosis—a mechanism exploited by tumors—and serves diverse roles across immunity and metabolism with significant therapeutic interest.
- Other names
- Integrin-associated protein (IAP)MER6/OA3
02
Mechanism of action
Monoclonal antibodies against CD47 designed to block the CD47–SIRPα interaction, promoting tumor cell elimination
03
Biological functions
Inhibition of phagocytosisRegulation of apoptosisRegulation of proliferationRegulation of adhesionRegulation of migrationRegulation of immune responseRegulation of angiogenesisCardiovascular homeostasisInflammationCellular self-renewalMetabolic plasticity
04
Disease associations
CancerFibrosisTransplantation rejection
05
Safety considerations
Potential effects on normal cells expressing physiological levels of CD47
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