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Target intelligence / Profile preview
Human Chorionic Gonadotropin Beta Chain (hCGβ)
- Target
- hCGβ
- Molecular classification
- Glycoprotein hormone subunit
01
Overview
The human chorionic gonadotropin beta chain (hCGβ) is the unique beta subunit of the glycoprotein hormone human chorionic gonadotropin (hCG). hCG is a key hormone in pregnancy, produced primarily by placental trophoblast cells. Detection of β-hCG in urine or serum forms the basis for most pregnancy tests and is also a tumor marker for certain cancers.
- Other names
- Beta-hCGhCG beta subunitCGB
02
Biological functions
Pregnancy maintenanceStimulation of corpus luteumProgesterone productionAngiogenesisImmunomodulationCell differentiationActivation of LH/CG receptor (indirectly)
03
Disease associations
Pregnancy complications (e.g., ectopic pregnancy)Gestational trophoblastic diseaseGerm cell tumors (e.g., choriocarcinoma, testicular cancer)
04
Safety considerations
Elevated levels outside pregnancy may indicate cancerFalse positive pregnancy tests
05
Biomarkers
PregnancyGerm cell tumorsGestational trophoblastic disease
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