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Target intelligence / Profile preview
Human Cluster of Differentiation 19 (CD19)
- Target
- CD19
- Molecular classification
- Type I transmembrane glycoprotein, Receptor
01
Overview
CD19 is a transmembrane glycoprotein expressed on all stages of B-lineage cells. It functions as a signaling adaptor molecule and part of the BCR co-receptor complex. Due to its restricted expression pattern, CD19 is a valuable biomarker and therapeutic target in B-cell malignancies. Forced expression in non-B-cell tumors allows for experimental evaluation of CD19-targeted therapies in novel contexts. Resistance mechanisms involve downregulation or loss of CD19 expression, sometimes reversible with demethylating agents.
- Other names
- B-lymphocyte antigen CD19B-cell surface antigen CD19
02
Mechanism of action
CAR-T therapies bind to CD19 expressing cells and induce cell lysis. Bispecific antibodies bind to both T-cells (via CD3) and CD19 expressing tumor cells, promoting T-cell mediated killing.
03
Biological functions
Signal transductionB-cell receptor signalingB-cell developmentBiomarker
04
Disease associations
CancerHematologic malignancies
05
Safety considerations
B-cell aplasia (on-target/off-tumor toxicity)Cytokine release syndrome (CRS)Neurological toxicity
06
Interacting drugs
CAR-T therapies
2 more in the full profile.
07
Biomarkers
CD19 expression levelCD19 surface density
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