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Target intelligence / Profile preview
Human Cytomegalovirus Glycoprotein B (gB)
- Target
- gB
- Molecular classification
- Viral Fusion Protein, Envelope Glycoprotein
01
Overview
Human cytomegalovirus glycoprotein B (gB) is a highly conserved, envelope-associated glycoprotein essential for the entry of human cytomegalovirus (HCMV) into host cells. It acts as the primary viral fusogen, mediating fusion between the viral envelope and host cell membranes. gB is required for initial virion attachment and subsequent stable binding. It also facilitates direct cell-to-cell spread of HCMV. gB elicits strong humoral immune responses, but most anti-gB antibodies are non-neutralizing due to epitope shielding by glycans.
- Other names
- HCMV gBUL55 proteinGlycoprotein BHHV-5 glycoprotein B
02
Mechanism of action
Viral entry inhibition (potential)
03
Biological functions
Viral entryMembrane fusionHost cell attachmentCell-to-cell spreadImmune evasion
04
Disease associations
InfectionHuman Cytomegalovirus Infection
05
Safety considerations
Epitope shielding by glycosylation hinders effective antibody neutralizationVaccines based solely on gB may have limited efficacy
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