Target intelligence / Profile preview

Human cytomegalovirus matrix protein pp65 (pp65)

Target: pp65
Molecular classification: Viral protein, Herpesviridae pp65 family, Matrix protein, Tegument protein, Phosphoprotein

Overview

Human cytomegalovirus (HCMV) matrix protein pp65 is a major structural and immunogenic component of the HCMV virion. It is located within the viral tegument and plays roles in immune evasion by inhibiting IRF3 and modulating cGAS, and in virion assembly. It is a dominant target antigen for CD8+ and CD4+ T-cells during HCMV infection.

Other names: Phosphoprotein UL83Tegument protein UL8365 kDa phosphoproteinMatrix phosphoprotein pp65

Biological functions

Immune evasionVirion assemblyVirion structureIRF3 inhibitionIFI16 recruitmentcGAS modulation

Disease associations

InfectionCytomegalovirus infection

Beyond the preview

Go deeper on Human cytomegalovirus matrix protein pp65 (pp65).

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Drug pipeline

Explore the programs pursuing this target and their development progress.

Drug candidates
Developers
Development stage

Clinical trials

Follow the clinical studies evaluating therapies directed at this target.

Trial design
Status
Readouts

Competitive landscape

Compare approaches across drug candidates, modalities, and indications.

Programs
Modalities
Indications

Literature & evidence

Investigate the research and source evidence behind target biology and development.

Publications
Sources
Analysis

Patents

Explore patent activity around therapies and technologies addressing this target.

Patents
Assignees
Technologies

Research & analysis

Connect target biology, drug development, and emerging evidence in your research.

Biology
Development news
Analysis

Bring the full picture into focus.

See how Gosset can support your research on Human cytomegalovirus matrix protein pp65 (pp65).

Explore the full profile