Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Human cytomegalovirus Pentameric complex (HCMV Pentamer)
- Target
- HCMV Pentamer
- Molecular classification
- Viral entry/fusion complex, Viral envelope glycoprotein complex, Other (herpesvirus envelope complex)
01
Overview
The HCMV Pentameric complex is a critical glycoprotein assembly on the surface of the human cytomegalovirus (HCMV) envelope. It comprises five subunits: glycoprotein H (gH), glycoprotein L (gL), and three viral proteins: UL128, UL130, and UL131A. This complex is essential for efficient infection of epithelial, endothelial, and myeloid lineage cells. The Pentameric complex binds host cell surface receptors—most notably neuropilin-2 (NRP2) and thrombomodulin (THBD)—to mediate viral attachment and entry. These interactions drive HCMV’s broad cellular tropism and are considered central for transmission and pathogenicity. Monoclonal antibodies targeting conformational epitopes on the Pentamer can effectively neutralize viral infectivity in susceptible cells, highlighting this complex as an important candidate for vaccine and therapeutic antibody development[1][4].
- Other names
- HCMV PentamerHCMV gH/gL/UL128-131A complexgH/gL/UL128/UL130/UL131A complex
02
Mechanism of action
Mechanisms involve neutralization by monoclonal antibodies preventing receptor binding and subsequent cell entry
03
Biological functions
Viral entry into epithelial and endothelial cellsHost cell receptor recognitionMediation of cell tropism
04
Disease associations
Infection (Human cytomegalovirus infection)
05
Safety considerations
viral escape mutantsimmunogenicity (for biologics)off-target immune reactions (in multi-target approaches)
06
Interacting drugs
Antiviral neutralizing antibodies (such as 13H11, 8I21)
1 more in the full profile.
07
Biomarkers
Presence of neutralizing anti-pentamer antibodies may correlate with protection from HCMV infection or efficacy of experimental vaccines
Beyond the preview
Go deeper on Human cytomegalovirus Pentameric complex (HCMV Pentamer).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Human cytomegalovirus Pentameric complex (HCMV Pentamer).