Target intelligence / Profile preview

Human cytomegalovirus phosphoprotein pp65 (pp65)

Target: pp65
Molecular classification: Phosphoprotein, Viral protein, Tegument protein

Overview

Human cytomegalovirus (HCMV) phosphoprotein pp65, also known as UL83, is the most abundant tegument protein in HCMV virions. It plays a critical role in virion assembly, immune evasion by inhibiting type I interferon production and cGAS activation, and is a major target for host immune responses. Due to its immunogenicity, it is a key marker for diagnostic assays and a potential vaccine target.

Other names: UL83Tegument protein UL83Matrix phosphoproteinMajor tegument component

Mechanism of action

N/A

Biological functions

Virion assemblyImmune evasionModulation of host immune responseScaffolding protein

Disease associations

InfectionHCMV-related diseasesCongenital cytomegalovirus infection

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