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Target intelligence / Profile preview
Human Double Minute 2 Protein (MDM2)
- Target
- MDM2
- Molecular classification
- E3 ubiquitin ligase
01
Overview
The human double minute 2 protein, commonly referred to as MDM2 or E3 ubiquitin-protein ligase Mdm2, is a nuclear-localized protein that functions primarily as an E3 ubiquitin ligase and is a critical negative regulator of the p53 tumor suppressor pathway. Overexpression or amplification of MDM2 leads to excessive degradation/inhibition of p53, promoting tumorigenesis. Due to its central role in regulating the key tumor suppressor protein p53—and frequent dysregulation in cancer—MDM2 is a major target for anticancer drug development.
- Other names
- E3 ubiquitin-protein ligase Mdm2
02
Mechanism of action
Disrupting the interaction between MDM2 and p53
03
Biological functions
p53 regulationCell cycle controlApoptosisDNA damage responseUbiquitinationRegulation of transcription
04
Disease associations
CancerLessel-Kubisch SyndromeAccelerated Tumor Formation
05
Safety considerations
Over-activation of p53 leading to unwanted cell death
06
Interacting drugs
MDM2 antagonists
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