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Target intelligence / Profile preview
Human Endogenous Retrovirus K Envelope Protein (HERV-K ENV)
- Target
- HERV-K ENV
- Molecular classification
- Retroviral envelope glycoprotein
01
Overview
The Human Endogenous Retrovirus K envelope protein (HERV-K ENV) is a glycoprotein encoded by the env gene of the HERV-K family. It mediates receptor recognition and membrane fusion, and its aberrant expression is associated with various cancers and neurodegenerative diseases. It is being explored as an immunotherapy target in melanoma.
- Other names
- HERV-K ENV proteinEnv protein
02
Mechanism of action
CAR-T therapies target melanoma cells expressing HERV-K ENV
03
Biological functions
Receptor recognitionMembrane fusionImmune modulationCell-cell fusion
04
Disease associations
CancerNeurodegenerative disease
05
Safety considerations
Potential off-target effects of CAR-T therapiesNeurotoxic effects when aberrantly expressed
06
Biomarkers
HERV-K ENV expression in melanoma cells
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