Human Epidermal Growth Factor Receptor 1 (EGFR/HER1)

Human Epidermal Growth Factor Receptor 1 (EGFR/HER1) is a transmembrane receptor tyrosine kinase that plays a critical role in cell growth, proliferation, differentiation, and survival. Upon ligand binding, EGFR undergoes dimerization and autophosphorylation, leading to the activation of downstream signaling pathways such as RAS-RAF-MEK-ERK and PI3K-AKT. Aberrant EGFR signaling is frequently observed in various cancers, making it a key therapeutic target. Therapeutic strategies include monoclonal antibodies and small molecule inhibitors that block ligand binding or tyrosine kinase activity.

Other names

ErbB-1ERBB1Receptor tyrosine-protein kinase erbB-1Proto-oncogene c-ErbB-1

Inhibition of tyrosine kinase activity or ligand binding, leading to reduced downstream signaling.