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Target intelligence / Profile preview
Human Epidermal Growth Factor Receptor 2 (HER2) dimerization (HER2 dimerization)
- Target
- HER2 dimerization
- Molecular classification
- Receptor, Tyrosine-protein kinase receptor
01
Overview
HER2 is a member of the epidermal growth factor receptor (EGFR) family and plays a crucial role in cell proliferation and growth. It is known for its ability to form homodimers and heterodimers with other ErbB family members, leading to the activation of various signaling pathways. In cancer, particularly breast cancer, HER2 overexpression or amplification is associated with aggressive disease and is targeted by several therapies. The process of HER2 dimerization is critical for its oncogenic activity and is a key target for therapeutic intervention.
- Other names
- HER2/neuERBB2
02
Mechanism of action
Inhibition of HER2 dimerization, Blocking of downstream signaling pathways (e.g., MAPK, PI3K/Akt)
03
Biological functions
Signal transductionCell proliferationCell growth
04
Disease associations
Cancer
05
Safety considerations
Cardiac toxicityInfusion reactions
06
Interacting drugs
2 more in the full profile.
07
Biomarkers
HER2 protein overexpressionHER2 gene amplification
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