Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Human Epidermal Growth Factor Receptor 2 Tyrosine Kinase Domain (HER2 TKD)
- Target
- HER2 TKD
- Molecular classification
- Receptor Tyrosine Kinase, Enzyme, Protein Kinase, Tyrosine Kinase
01
Overview
The Human Epidermal Growth Factor Receptor 2 (HER2) Tyrosine Kinase Domain is the intracellular catalytic domain of the HER2 receptor, a transmembrane tyrosine kinase receptor involved in cell growth, survival, and differentiation. It is activated by dimerization, leading to autophosphorylation and downstream signaling through the MAPK and PI3K/AKT pathways. HER2 overexpression or amplification is implicated in various cancers, making it a key therapeutic target. Unlike other HER family members, HER2 does not directly bind ligands, instead relying on dimerization for activation.
- Other names
- ErbB2 Tyrosine Kinase DomainCD340 Tyrosine Kinase DomainNeu Tyrosine Kinase Domain
02
Mechanism of action
Inhibition of tyrosine kinase activity, Antibody-dependent cell-mediated cytotoxicity (ADCC)
03
Biological functions
Signal transductionCell growthCell survivalCell differentiationCell proliferationAutophosphorylation
04
Disease associations
CancerBreast cancerGastric cancerGastroesophageal cancerOvarian cancerEndometrial cancerBladder cancerLung cancerColon cancer
05
Safety considerations
CardiotoxicityInfusion-related reactionsDiarrhea (with tyrosine kinase inhibitors)Off-target effects on EGFR and other kinases
06
Interacting drugs
Lapatinib
2 more in the full profile.
07
Biomarkers
HER2 amplificationHER2 overexpression
Beyond the preview
Go deeper on Human Epidermal Growth Factor Receptor 2 Tyrosine Kinase Domain (HER2 TKD).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Human Epidermal Growth Factor Receptor 2 Tyrosine Kinase Domain (HER2 TKD).